Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis

@article{Fidler1986RationaleAM,
  title={Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis},
  author={Isaiah Josh Fidler},
  journal={Cancer and Metastasis Reviews},
  year={1986},
  volume={5},
  pages={29-49}
}
Human neoplasms are biologically heterogeneous. The extensive cellular diversity found in malignant neoplasms is generated by the rapid emergence of clonal subpopulations of tumor cells with different properties that include invasion, metastasis and responsiveness to treatment. Studies in rodent systems have indicated that cancer metastases can be clonal in their origin and that different metastases can originate from different progenitor cells from the primary tumor. This metastatic… CONTINUE READING
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