Rationale and design of the ATTRACT Study: a multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis.

@article{Vedantham2013RationaleAD,
  title={Rationale and design of the ATTRACT Study: a multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis.},
  author={Suresh Vedantham and Samuel Z. Goldhaber and Susan R. Kahn and Jim Julian and Elizabeth A. Magnuson and Michael R. Jaff and Timothy P. Murphy and David Jacques Cohen and Anthony James Comerota and Heather L Gornik and Mahmood Razavi and Lawrence Lewis and Clive Kearon},
  journal={American heart journal},
  year={2013},
  volume={165 4},
  pages={523-530.e3}
}
BACKGROUND Current standard therapy for patients with acute proximal deep vein thrombosis (DVT) consists of anticoagulant therapy and graduated elastic compression stockings. Despite use of this strategy, the postthrombotic syndrome (PTS) develops frequently, causes substantial patient disability, and impairs quality of life. Pharmacomechanical catheter-directed thrombolysis (PCDT), which rapidly removes acute venous thrombus, may reduce the frequency of PTS. However, this hypothesis has not… CONTINUE READING

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