Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran.

@article{Ezekowitz2009RationaleAD,
  title={Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran.},
  author={Michael Ezekowitz and Stuart J. Connolly and Amit Parekh and Paul A. Reilly and Jeanne Varrone and Susan M. Wang and Jonas Oldgren and Ellison Themeles and Lars Wallentin and Salim Yusuf},
  journal={American heart journal},
  year={2009},
  volume={157 5},
  pages={805-10, 810.e1-2}
}
Vitamin K antagonists (VKAs) are effective for stroke prevention in patients with atrial fibrillation (AF) but are difficult to use. Dabigatran etexilate is a prodrug that is rapidly converted to the active direct thrombin inhibitor dabigatran. It is administered in a fixed dose without laboratory monitoring and is being compared with warfarin (international normalized ratio 2-3) in the RE-LY trial. Two doses of dabigatran (110 and 150 mg BID) are being evaluated. RE-LY is a phase 3… CONTINUE READING
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