Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation.

@article{Rollema2007RationalePA,
  title={Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation.},
  author={Hans Rollema and Jotham W. Coe and Leslie K. Chambers and Raymond S. Hurst and Stephen M. Stahl and Kathryn E. Williams},
  journal={Trends in pharmacological sciences},
  year={2007},
  volume={28 7},
  pages={316-25}
}
Most smokers repeatedly fail in their attempts to stop smoking because of the addictive nature of the nicotine in tobacco products. Nicotine dependence is probably mediated through the activation of multiple subtypes of neuronal nicotinic acetylcholine receptor (nAChR), among which the mesolimbic alpha(4)beta(2) subtype has a pivotal role. Here, we discuss the rationale for and the design of alpha(4)beta(2) nAChR partial agonists as novel treatments for tobacco addiction. Such agents are… CONTINUE READING
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