Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices.

@article{Evans2014RationalSO,
  title={Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices.},
  author={Elizabeth Evans and Ellen Fl{\'a}via Moreira Gabriel and Wendell Karlos Tomazelli Coltro and Carlos D. Garcia},
  journal={The Analyst},
  year={2014},
  volume={139 9},
  pages={
          2127-32
        }
}
A systematic investigation was conducted to study the effect of paper type on the analytical performance of a series of microfluidic paper-based analytical devices (μPADs) fabricated using a CO2 laser engraver. Samples included three different grades of Whatman chromatography paper, and three grades of Whatman filter paper. According to the data collected and the characterization performed, different papers offer a wide range of flow rate, thickness, and pore size. After optimizing the channel… 
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118 Citations

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This chapter describes two different methodologies used to improve the analytical performance of colorimetric paper-based biosensors, produced by a stamping process and CO2 laser ablation and modified, respectively, through an oxidation step and incorporation of silica nanoparticles on the paper structure.
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This study demonstrates how the characterization of fluidic compatibility between substrates, chemical compatibility between reagents and substrate, sample pH, and sample transport can be used to inform device design in the context of a two-reaction detection scheme for phenylalanine in porous materials.
A rapid real-time quantification in hybrid paper-polymer centrifugal optical devices.
Technical aspects and challenges of colorimetric detection with microfluidic paper-based analytical devices (μPADs) - A review.
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