Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices.

  title={Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices.},
  author={Elizabeth Evans and Ellen Fl{\'a}via Moreira Gabriel and Wendell Karlos Tomazelli Coltro and Carlos D. Garcia},
  journal={The Analyst},
  volume={139 9},
A systematic investigation was conducted to study the effect of paper type on the analytical performance of a series of microfluidic paper-based analytical devices (μPADs) fabricated using a CO2 laser engraver. Samples included three different grades of Whatman chromatography paper, and three grades of Whatman filter paper. According to the data collected and the characterization performed, different papers offer a wide range of flow rate, thickness, and pore size. After optimizing the channel… 
Modification of microfluidic paper-based devices with silica nanoparticles.
The potential of silica nanoparticles to avoid the washing away effect and improve the color uniformity and intensity in colorimetric bioassays performed on μPADs is demonstrated.
Enhanced Performance of Colorimetric Biosensing on Paper Microfluidic Platforms Through Chemical Modification and Incorporation of Nanoparticles.
This chapter describes two different methodologies used to improve the analytical performance of colorimetric paper-based biosensors, produced by a stamping process and CO2 laser ablation and modified, respectively, through an oxidation step and incorporation of silica nanoparticles on the paper structure.
In low-resource settings, where functional laboratories are not that developed, the potential of microfluidics can be exploited to deliver health care as a diagnostic device in a very cost effective
Characterization methods in porous materials for the rational design of multi-step processing in the context of a paper microfluidic phenylalanine test.
This study demonstrates how the characterization of fluidic compatibility between substrates, chemical compatibility between reagents and substrate, sample pH, and sample transport can be used to inform device design in the context of a two-reaction detection scheme for phenylalanine in porous materials.
Development of microfluidic paper based analytical devices (µPADS) for the detection of calcium and magnesium ions
Microfluidic paper-based analytical devices (µPADs) have been developed using several patterning technologies to reproducibly create inexpensive lab-on-chip type analytical tools. Consequently, these


Low-cost fabrication of paper-based microfluidic devices by one-step plotting.
A facile method for one-step fabrication of paper-based microfluidic devices, by simply using commercially available permanent markers and metal templates with specific patterns, which holds great potential to find wide applications especially in remote regions and resource-limited environments such as small laboratories and private clinics.
Laminated paper-based analytical devices (LPAD): fabrication, characterization, and assays
Paper-based microfluidic devices have recently garnered an increasing interest in the literature. The majority of these devices were produced by patterning hydrophobic zones in hydrophilic paper via
Quantifying colorimetric assays in paper-based microfluidic devices by measuring the transmission of light through paper.
Measuring transmittance through paper represents a new method of quantitative detection that expands the potential functionality of micro-PADs and is potentially attractive for use in resource-limited environments and developing countries.
Inkjet-printed microfluidic multianalyte chemical sensing paper.
This paper presents an inkjet printing method for the fabrication of entire microfluidic multianalyte chemical sensing devices made from paper suitable for quantitative analysis, requiring only a
Progress in patterned paper sizing for fabrication of paper-based microfluidic sensors
In this paper, we report the progress in using paper sizing chemistry to fabricate patterned paper for chemical and biological sensing applications. Patterned paper sizing uses paper sizing agents to
Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving
This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster
Electrochemical detection for paper-based microfluidics.
This study shows the successful integration of paper-based microfluidics and electrochemical detection as an easy-to-use, inexpensive, and portable alternative for point of care monitoring.
Bioactive paper provides a low-cost platform for diagnostics
  • R. Pelton
  • Engineering
    TrAC Trends in Analytical Chemistry
  • 2009