Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins.

@article{Schrank2009RationalMO,
  title={Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins.},
  author={Travis P Schrank and David Wayne Bolen and Vincent J. Hilser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 40},
  pages={16984-9}
}
Elucidating the complex interplay between protein structure and dynamics is a prerequisite to an understanding of both function and adaptation in proteins. Unfortunately, it has been difficult to experimentally decouple these effects because it is challenging to rationally design mutations that will either affect the structure but not the dynamics, or that will affect the dynamics but not the structure. Here we adopt a mutation approach that is based on a thermal adaptation strategy observed in… CONTINUE READING

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