Rational interleukin-2 therapy.

@article{Smith1997RationalIT,
  title={Rational interleukin-2 therapy.},
  author={Kendall A Smith},
  journal={The cancer journal from Scientific American},
  year={1997},
  volume={3 Suppl 1},
  pages={S137-40}
}
  • Kendall A Smith
  • Published 1997 in The cancer journal from Scientific American
The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the structure-activity relationships of the cytokine-receptor interaction. Thus, the therapeutic index should be determined, and the goal should be to augment the function of the immune system in a variety of clinical situations, not necessarily… CONTINUE READING