Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations.

@article{Liu2002RationalDO,
  title={Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations.},
  author={Ping Hsin Liu and Markus U. M{\"u}ller and Hartmut Derendorf},
  journal={International journal of antimicrobial agents},
  year={2002},
  volume={19 4},
  pages={285-90}
}
At the moment, the most common pharmacokinetic/pharmacodynamic (PK/PD) approaches for anti-infective agents, such as time above MIC, C(max)/MIC and AUC(24)/MIC, rely on plasma concentration as the PK input value and minimum inhibitory concentration (MIC) as the PD input value. However, only the free tissue concentrations of antibiotics at the target site are responsible for the therapeutic effect. Using plasma concentrations frequently overestimates the target site concentrations and therefore… CONTINUE READING

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