Rational design of potent antagonists to the human growth hormone receptor.

@article{Fuh1992RationalDO,
  title={Rational design of potent antagonists to the human growth hormone receptor.},
  author={Germaine Fuh and Brian C Cunningham and Rikiro Fukunaga and Shigekazu Nagata and David V. Goeddel and James A. Wells},
  journal={Science},
  year={1992},
  volume={256 5064},
  pages={1677-80}
}
A hybrid receptor was constructed that contained the extracellular binding domain of the human growth hormone (hGH) receptor linked to the transmembrane and intracellular domains of the murine granulocyte colony-stimulating factor receptor. Addition of hGH to a myeloid leukemia cell line (FDC-P1) that expressed the hybrid receptor caused proliferation of these cells. The mechanism for signal transduction of the hybrid receptor required dimerization because monoclonal antibodies to the hGH… CONTINUE READING
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