Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent.

@article{Jeong2014RationalDO,
  title={Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent.},
  author={Young-Su Jeong and Jung Min Choi and Hyun-Ho Kyeong and Jae-Youl Choi and E Kim and Hak-Sung Kim},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={449 3},
  pages={263-7}
}
V-type nerve agents, known as VX, are organophosphate (OP) compounds, and show extremely toxic effects on human and animals by causing cholinergic overstimulation of synapses. The bacterial organophosphorus hydrolase (OPH) has attracted much attention for detoxifying V-type agents through hydrolysis of the P-S bond. However, low catalytic efficiency of OPH has limited the practical use of the enzyme. Here we present rational design of OPH with high catalytic efficiency for a V-type nerve agent… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 28 references

P

  • I. Cherny
  • Greisen Jr., Y. Ashani, S.D. Khare, G. Oberdorfer…
  • 2013
1 Excerpt

M

  • N. Schmid, A. P. Eichenberger, A. Choutko, S. Riniker
  • Winger, A.E. Mark, W.F. van Gunsteren, Definition…
  • 2011
1 Excerpt

Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides

  • C. Mee-Hie Cho, A. Mulchandani, W. Chen
  • Protein Eng. Des. Sel. 19
  • 2006
1 Excerpt

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