Rational design of hetero-ring-expanded guanine analogs with enhanced properties for modified DNA building blocks.

Abstract

The properties and modes of recognition of physiological DNAs associated with the four natural nucleobases might be extended, in principle, by the design of non-natural nucleobase derivatives. The goal is an expansion of the genetic alphabet, with the possible outcome of producing new DNAs with improved physical or biological properties. In this work, a new… (More)

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