Rational design of alpha-helical antimicrobial peptide with Val and Arg residues.

Abstract

OBJECTIVE The amphipathic alpha-helical peptide is an important class of antimicrobial peptides. In this study, a 16-residue-long peptide (VGR16) composed of 8 Val residues in the nonpolar face and 5 Arg residues in the polar face was designed based on the helical wheel projection to produce antimicrobial peptide with improved antibacterial activity… (More)

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