Rational design of a new series of pronucleotide.

@article{Beltran2001RationalDO,
  title={Rational design of a new series of pronucleotide.},
  author={Thierry Beltran and David Egron and Alain Pompon and Isabelle Gautier Lefebvre and Christian P{\'e}rigaud and Gilles Gosselin and A Aubertin and Imbach Jl},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 13},
  pages={
          1775-7
        }
}
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK(-) cell line, which proves 5'-AZTMP delivery. 
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