Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation.


Viruses that replicate in the cytoplasm cannot access the host nuclear capping machinery. These viruses have evolved viral methyltransferase(s) to methylate N-7 and 2'-O cap of their RNA; alternatively, they "snatch" host mRNA cap to form the 5' end of viral RNA. The function of 2'-O methylation of viral RNA cap is to mimic cellular mRNA and to evade host… (More)
DOI: 10.1128/JVI.02806-12


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