Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

@article{Martin2003RationalDO,
  title={Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes},
  author={Lo{\"i}c Martin and François Stricher and Doroth{\'e}e Miss{\'e} and Francesca Sironi and Martine Pugni{\`e}re and Philippe Barthe and Rafael Prado-Gotor and Isabelle Freulon and Xavier Magne and Christian Roumestand and Andr{\'e} M{\'e}nez and Paolo Lusso and Francisco Veas and Claudio De Vita},
  journal={Nature Biotechnology},
  year={2003},
  volume={21},
  pages={71-76}
}
The conserved surfaces of the human immunodeficiency virus (HIV)-1 envelope involved in receptor binding represent potential targets for the development of entry inhibitors and neutralizing antibodies. Using structural information on a CD4-gp120-17b antibody complex, we have designed a 27-amino acid CD4 mimic, CD4M33, that presents optimal interactions with gp120 and binds to viral particles and diverse HIV-1 envelopes with CD4-like affinity. This mini-CD4 inhibits infection of both… CONTINUE READING