Rational design of Salmonella-based vaccination strategies.

  title={Rational design of Salmonella-based vaccination strategies.},
  author={Simone Spreng and Guido Dietrich and Gerald Weidinger},
  volume={38 2},
A permanently growing body of information is becoming available about the quality of protective immune responses induced by mucosal immunization. Attenuated live bacterial vaccines can be administered orally and induce long-lasting protective immunity in humans without causing major side effects. An attenuated Salmonella enterica serovar Typhi strain is registered as live oral vaccine against typhoid fever and has been in use for more than two decades. Recombinant attenuated Salmonella strains… CONTINUE READING
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