Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on Docetaxel

@article{Dash2020RationalDO,
  title={Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on Docetaxel},
  author={Shruti Gamya Dash and Charu Suri and P.K. Nagireddy and Srinivas Kantevari and Pradeep Kumar Naik},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2020},
  volume={39},
  pages={5276 - 5289}
}
  • S. Dash, C. Suri, P. K. Naik
  • Published 1 July 2020
  • Chemistry, Biology
  • Journal of Biomolecular Structure and Dynamics
Abstract Docetaxel (DOX) based combination therapy is a novel therapeutic strategy that attracts great interest in breast cancer treatment but its clinical utility got limited due to side effects. In contrast, noscapine, an antitussive drug showed antitumor activity against many cancers without any side effects that targets microtubules and attenuates its dynamic instability. In the quest for an increase in the anticancer activity of noscapine, we strategically designed a novel derivative, 9… 
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Combination Regimen of Amino-Noscapine and Docetaxel for Evaluation of Anticancer Activity
TLDR
The cytotoxic effect of DOX was reduced significantly in combined treatment with amino-noscapine (20 μM) and the induction of apoptosis was more effective in the combined treatment of both the compounds.
Combination of docetaxel and newly synthesized 9-Br-trimethoxybenzyl-noscapine improve tubulin binding and enhances antitumor activity in breast cancer cells
Rational design of novel N‐alkyl amine analogues of noscapine, their chemical synthesis and cellular activity as potent anticancer agents
TLDR
It is concluded that 9‐(N‐arylmethyl amino) noscapinoids, 15–17 have a high probability to be a novel therapeutic agent for breast cancers.
Structure Based Design of Tubulin Binding 9-Arylimino Noscapinoids: Chemical Synthesis and Experimental Validation Against Breast Cancer Cell Lines
TLDR
It is concluded that 9-arylimino noscapinoids 4-6 have tremendous potential as chemotherapeutic agents for the treatment of breast cancer.
Synergistic interaction of N‐3‐Br‐benzyl‐noscapine and docetaxel abrogates oncogenic potential of breast cancer cells
TLDR
The combination dose regimen of Br‐Bn‐Nos and DOX blocks the cell cycle progression at the G2/M phase and induces apoptosis to cancer cells more effectively compared with the single regimen.
Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review
TLDR
This study aimed to elaborate on the possible mechanisms of noscapine against different disorders and attenuates the dynamic properties of microtubules and arrests the cell cycle in the G2/M phase.
Chemical diversity of dietary phytochemicals and their mode of chemoprevention

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