Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.

@article{Daele2007RationalDO,
  title={Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.},
  author={Ineke Van Daele and H{\'e}l{\'e}ne Munier-Lehmann and Matheus Froeyen and Jan Balzarini and Serge van Calenbergh},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 22},
  pages={5281-92}
}
Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray structure of TMPK of M. tuberculosis (TMPKmt), as well as the structure of an earlier serendipitously discovered dimeric thymidine inhibitor, laid the foundation for the design of potent… CONTINUE READING