Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents.

@article{Shaik2017RationalDA,
  title={Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents.},
  author={Thokhir Basha Shaik and Syed Mohammed Ali Hussaini and Vadithe Lakshma Nayak and M Lakshmi Sucharitha and M Shaheer Malik and Ahmed Kamal},
  journal={Bioorganic & medicinal chemistry letters},
  year={2017},
  volume={27 11},
  pages={
          2549-2558
        }
}
Based on our previous results and literature precedence, a series of 2-anilinopyridinyl-benzothiazole Schiff bases were rationally designed by performing molecular modeling experiments on some selected molecules. The binding energies of the docked molecules were better than the E7010, and the Schiff base with trimethoxy group on benzothiazole moiety, 4y was the best. This was followed by the synthesis of a series of the designed molecules by a convenient synthetic route and evaluation of their… CONTINUE READING
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