Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth.

@article{Li2008RationalDS,
  title={Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth.},
  author={Minfen Li and Yali Li and Xuanhao Liao and Jingxian Liu and Haina Qin and Zhi-cheng Xiao and Jianxing Song},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={373 4},
  pages={498-503}
}
The interaction between Nogo-66 and its receptor NgR represents a promising target for designing drugs to treat CNS axonal injury which often leads to permanent disability. Unfortunately, the isolated Nogo-66 is highly insoluble while its truncated form Nogo-40 is soluble but unstructured, thus retarding further characterization and application. Here, we rationally design another soluble form Nogo-54. CD and NMR characterization reveals that Nogo-54 is structured, and importantly, is able to… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…