Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents.

@article{Patel2021RationalDC,
  title={Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents.},
  author={Amiya Kumar Patel and Rajesh Kumar Meher and Praveen Kumar Reddy and Ravi Kumar Pedapati and Pratyush Pragyandipta and Srinivas Kantevari and Manas R. Naik and Pradeep Kumar Naik},
  journal={Journal of molecular graphics \& modelling},
  year={2021},
  volume={106},
  pages={
          107933
        }
}
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3 Citations

3 Citations

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Citation Type

Development of 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents for the management of breast cancer.
TLDR
1,3-diynyl-noscapinoids have great potential to be a novel therapeutic agent for breast cancers and cytotoxicity activity was validated based on cellular studies using human breast adenocarcinoma, a panel of primary breast tumor cells and one normal human embryonic kidney cell.
Structure Based Design of Tubulin Binding 9-Arylimino Noscapinoids: Chemical Synthesis and Experimental Validation Against Breast Cancer Cell Lines
TLDR
It is concluded that 9-arylimino noscapinoids 4-6 have tremendous potential as chemotherapeutic agents for the treatment of breast cancer.
Targeted Synthesis and Antitumor Activity In Vitro Macrodiolides Containing 1Z,5Z-Diene and 1,3-Diyne Moieties

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TLDR
The study reported here identified potent, third generation noscapinoids as new anti-cancer agents that perturbed DNA synthesis, delayed the cell cycle progression at G2/M phase, and induced apoptotic cell death in cancer cells.
Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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