Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc01320d Click here for additional data file.

@inproceedings{Proctor2015RationalCD,
  title={Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator†
†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc01320d
Click here for additional data file.

},
  author={Elizabeth A Proctor and Pradeep Kota and Andrei A. Aleksandrov and Lihua He and John R. Riordan and Nikolay V. Dokholyan},
  booktitle={Chemical science},
  year={2015}
}
Many cellular functions necessary for life are tightly regulated by protein allosteric conformational change, and correlated dynamics between protein regions has been found to contribute to the function of proteins not previously considered allosteric. The ability to map and control such dynamic coupling would thus create opportunities for the extension of current therapeutic design strategy. Here, we present an approach to determine the networks of residues involved in the transfer of… CONTINUE READING

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