Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL.

  title={Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL.},
  author={S Kim and Deepak Rai and Morgan R. McKeller and Ricardo Aguiar},
  volume={113 24},
Identification of rational therapeutic targets is an important strategy to improve the cure rate of diffuse large B-cell lymphoma (DLBCL). We previously showed that inhibition of the phosphodiesterase 4B (PDE4B) unleashes cyclic-AMP (cAMP) inhibitory effects toward the PI3K/AKT pathway and induces apoptosis. These data raised important considerations as to which upstream regulators mediate cAMP inhibition of PI3K/AKT, and how identifying this signaling route could be translated into clinical… CONTINUE READING
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