Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL.


Identification of rational therapeutic targets is an important strategy to improve the cure rate of diffuse large B-cell lymphoma (DLBCL). We previously showed that inhibition of the phosphodiesterase 4B (PDE4B) unleashes cyclic-AMP (cAMP) inhibitory effects toward the PI3K/AKT pathway and induces apoptosis. These data raised important considerations as to… (More)
DOI: 10.1182/blood-2009-02-206128


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