Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.

@article{Pegram2004RationalCO,
  title={Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.},
  author={Mark D. Pegram and Gottfried Konecny and Carminda O'Callaghan and Malgorzata Beryt and Richard J Pietras and Dennis J Slamon},
  journal={Journal of the National Cancer Institute},
  year={2004},
  volume={96 10},
  pages={
          739-49
        }
}
BACKGROUND Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers that overexpress HER2. We characterized interactions between trastuzumab and chemotherapeutic agents commonly used in the treatment of breast cancer. METHODS Multiple drug effect/combination index isobologram analysis was used to study the efficacy of chemotherapeutic drug plus trastuzumab combinations tested against four HER2… CONTINUE READING

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