Rational approach to discover multipotent anti-Alzheimer drugs.

  title={Rational approach to discover multipotent anti-Alzheimer drugs.},
  author={Michela Rosini and Vincenza Andrisano and Manuela Bartolini and Maria Laura Bolognesi and Patrizia Hrelia and Anna Minarini and Andrea Tarozzi and Carlo Melchiorre},
  journal={Journal of medicinal chemistry},
  volume={48 2},
The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits the catalytic activity of AChE and AChE-induced amyloid-beta aggregation and protects against reactive oxygen species. Thus, it emerged as a valuable pharmacological tool to investigate Alzheimer's disease… CONTINUE READING
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