Rational Design of a Combination Medication for the Treatment of Obesity
@article{Greenway2009RationalDO, title={Rational Design of a Combination Medication for the Treatment of Obesity}, author={Frank L. Greenway and Martha Jo Whitehouse and Maria Guttadauria and James W. Anderson and Richard L. Atkinson and Ken Fujioka and Kishore M Gadde and Alok K. Gupta and Patrick M O'Neil and Donald Schumacher and D K Smith and Eduardo Dunayevich and Gary D. Tollefson and Eckard San Diego Weber and Michael A. Cowley}, journal={Obesity}, year={2009}, volume={17} }
Existing obesity therapies are limited by safety concerns and modest efficacy reflecting a weight loss plateau. [] Key Method In vitro electrophysiologic experiments were conducted to determine the extent to which BUP+NAL stimulated hypothalamic pro-opiomelanocortin (POMC) neurons in mouse brain. A subsequent study further characterized the effect of combination BUP+NAL treatment on food intake in lean and obese mice.
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