Rational Design of Tryptophan‐Rich Antimicrobial Peptides with Enhanced Antimicrobial Activities and Specificities

@article{Yu2010RationalDO,
  title={Rational Design of Tryptophan‐Rich Antimicrobial Peptides with Enhanced Antimicrobial Activities and Specificities},
  author={Hui‐Yuan Yu and Kuo‐Chun Huang and Bak‐Sau Yip and Chih-Hsiang Tu and Heng-Li Chen and Hsi-Tsung Cheng and Jyawei Cheng},
  journal={ChemBioChem},
  year={2010},
  volume={11}
}
Trp‐rich antimicrobial peptides play important roles in the host innate defense mechanism of many plants and animals. A series of short Trp‐rich peptides derived from the C‐terminal region of Bothrops asper myothoxin II, a Lys49 phospholipase A2 (PLA2), were found to reproduce the antimicrobial activities of their parent molecule. Of these peptides, KKWRWWLKALAKK—designated PEM‐2—was found to display improved activity against both Gram‐positive and Gram‐negative bacteria. To improve the… 

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