• Corpus ID: 24883201

Rational Design of Antibiotic Treatment Plans

@article{Mira2017RationalDO,
  title={Rational Design of Antibiotic Treatment Plans},
  author={Portia Mira and Kristina Crona and Devin Greene and Juan Meza and Bernd Sturmfels and Miriam Barlow},
  journal={arXiv: Populations and Evolution},
  year={2017}
}
Author(s): Mira, Portia M; Crona, Kristina; Greene, Devin; Meza, Juan C; Sturmfels, Bernd; Barlow, Miriam | Abstract: The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to overcoming this challenge. Here we present a data-driven mathematical approach for developing antibiotic treatment plans that can reverse the… 
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3 Citations

3 Citations

Exploiting evolutionary non-commutativity to prevent the emergence of bacterial antibiotic resistance
TLDR
A general mathematical model of evolution is developed that can be used to understand, and avoid, the emergence of antibiotic resistance and suggests a new strategy in the war against antibiotic-therapy-resistant organisms.
Chapter 3 – Adaptation and Fitness Graphs
Antibiotics Time Machine is NP-hard
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The antibiotics time machine is shown to be NP-hard in general, a variation of the Markov decision process.

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