Ratio of transcription factor PHF10 splice variants in lymphocytes as a molecular marker of Parkinson’s disease

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and causes degeneration of dopaminergic neurons in the nigrostriatal system of the brain. PHF10 is one of the most important regulatory subunits of the SWI/SNF chromatin-remodeling protein complex, which controls the gene function and chromatin state in neurons. Two alternative… (More)
DOI: 10.1134/S0026893316040130

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