Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures.

The physiological activity of many proteins can be regulated by S-nitrosylation or reaction of nitric oxide (NO)-related species with cysteine residues to produce S-nitrosoproteins (S-nitrosothiols). However, S-nitrosothiols, such as S-nitrosocysteine (SNOC) and S-nitrosohomocysteine (SNHC), can also be neurotoxic by generating NO which reacts with… (More)