Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide.

@article{Casey1977RatesOF,
  title={Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide.},
  author={Jonathan Casey and Naomi Davidson},
  journal={Nucleic acids research},
  year={1977},
  volume={4 5},
  pages={1539-52}
}
The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA:DNA rates are negligible and RNA:DNA rates close to optimal. 

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Methods in Enzymology Vol. XXIX part E 363-418

  • R. C. Deonier, E. Ohtsubo, H. J. Lee, N. Davidson
  • J. Mol. Biol
  • 1972

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