Rates of Molecular Evolution in RNA Viruses: A Quantitative Phylogenetic Analysis

@article{Jenkins2001RatesOM,
  title={Rates of Molecular Evolution in RNA Viruses: A Quantitative Phylogenetic Analysis},
  author={Gareth M. Jenkins and Andrew Rambaut and Oliver G. Pybus and Edward C. Holmes},
  journal={Journal of Molecular Evolution},
  year={2001},
  volume={54},
  pages={156-165}
}
The study of rates of nucleotide substitution in RNA viruses is central to our understanding of their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA viruses using a recently developed maximum likelihood phylogenetic method. This analysis revealed a significant relationship between genetic divergence and isolation time for an extensive array of RNA viruses, although more rate variation was usually present among lineages than would be expected under the… 
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