Rates of HBV, HCV, HDV and HIV type 1 among pregnant women and HIV type 1 drug resistance-associated mutations in breastfeeding women on antiretroviral therapy

  title={Rates of HBV, HCV, HDV and HIV type 1 among pregnant women and HIV type 1 drug resistance-associated mutations in breastfeeding women on antiretroviral therapy},
  author={Judith N. Torimiro and Aubin Joseph Nanfack and William Ako Takang and Claude Kalla Keou and Awum Nchenda Joyce and Kevin Pene Njefi and Kimbong Agyingi and Ir{\'e}n{\'e}e Domkam and D{\'e}sir{\'e} Takou and Sylvie Moudourou and Samuel Martin Sosso and Robinson Enow Mbu},
  journal={BMC Pregnancy and Childbirth},
BackgroundHBV, HCV, HDV and HIV are blood borne and can be transmitted from mother-to-child. Reports of HBV infection rates show up to 11.9% in Cameroon while for HCV, the rate is less than 2%. More so, as pregnant women get enrolled in the HIV PMTCT Programme and stay in the care continuum, selection of HIV-1 drug resistant strains is evident. We sought to determine the seroprevalence of HBV, HCV, HDV and HIV among pregnant women, assess their knowledge, attitudes and practices on transmission… Expand
4 Citations
High Vaccination Coverage against Hepatitis B Infection and Profile of Biomarkers of Infection in Children less than 60 months of age.
The frequency of Hepatitis B infection biomarkers and determinants of transmission in children aged less than 60 months of age and routine testing are key interventions in preventing vertical transmission of HBV. Expand
Co-infection and Risk Factors Associated with STIs among Pregnant Women in Rural Health Facilities in Nigeria: A Retrospective Study
Conclusively, due to medium HBV prevalence and a high prevalence of HCV and syphilis observed, attention should be paid to blood screening before transfusion by health workers. Expand
Viral hepatitis and pregnancy
The epidemiology of acute and chronic viral hepatitis infection in pregnancy, the effect of pregnancy on the course of viral infection and, conversely, the influence of the viral infection on maternal and infant outcomes, including MTCT are presented. Expand
A mixed-methods evaluation of hepatitis B knowledge, attitudes, and practices among migrant women in Thailand
Limited knowledge of HBV among migrant women can be improved by counselling that emphasizes actionable knowledge such as vaccination schedule as well as appropriate visual aids and timely repetition over the course of the antenatal period. Expand


HIV-1 pol gene polymorphism and antiretroviral resistance mutations in drug-naive pregnant women in Yaoundé, Cameroon.
The present study aimed to investigate whether genetic polymorphisms were present in RT and protease (PR) of HIV-1 genes at positions affecting the susceptibility to ARV and to evaluate baseline drug resistance among HIV- 1-infected pregnant women naive to NVP in Yaounde Cameroon. Expand
A low proportion of HBeAg among HBsAg-positive pregnant women with known HIV status could suggest low perinatal transmission of HBV in Cameroon
A high prevalence of HBsAg with very low proportion of HBeAg in Cameroonian pregnant women is indicated, which suggests that horizontal transmission could be the most common mechanism of HBV infections in Cameroon. Expand
Co-infection of hepatitis B virus and hepatitis Delta virus in Yaounde-Cameroon.
To determine the seroprevalence of HDV as well as the virological and clinical characteristics of HBV mono-infected and HBV/HDV co- infected patients, treatment-naive HBV- Infected patients from Yaounde are included. Expand
High Endemicity and Low Molecular Diversity of Hepatitis B Virus Infections in Pregnant Women in a Rural District of North Cameroon
The results confirm the high prevalence and low molecular diversity of HBV in Far Northern Cameroon; more than 20% of the infected women were highly viremic, suggesting a high rate ofHBV perinatal transmission and supporting the WHO recommendation to vaccinate at birth against hepatitis B. Expand
HIV and Hepatitis C Virus Coinfection, Cameroon
The prevalence of HIV/HCV coinfection in the general population of Cameroon is investigated, and the HCV seroprevalence was associated with age (<45 vs. ≥45 years, odds ratio [OR] 13.04; 95% CI 6.73–25.30; p<0.001), sex (men vs. women, OR 2.47; p = 0.01). Expand
Characterization of drug resistance mutations in naïve and ART‐treated patients infected with HIV‐1 in Yaounde, Cameroon
The high level of drug resistance observed in the cohort is alarming because this occurred as a result of only few years of treatment, and adherence to therapy, adequate education of physicians, and the appropriate use of genotypic resistance assay are critical points of intervention for the improvement of patient care. Expand
The prevalence of hepatitis B and C viral infections among pregnant women
The prevalence of the Hepatitis B virus (HBV) among pregnant women in this study area is of intermediate endemicity (12.5%), which showed that the expected risk factors had significant outcome. Expand
Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaoundé, Cameroon.
It is observed that a proportion of study participants had HIV-1 drug resistance associated mutations (RAMs) and data generated could help strengthen the current PMTCT programmes within the country. Expand
HIV‐1 reverse transcriptase drug‐resistance mutations in chronically infected individuals receiving or naïve to HAART in Cameroon
Strikingly, among the 21 drug‐naïve individuals, 24% harbored viruses with drug‐resistance mutations, suggesting that HIV‐1 drug‐resistant variants are being transmitted in Cameroon, which emphasizes the need for extensive monitoring of resistance mutations and the introduction of a second‐line HAART strategy. Expand
Prevalence, correlates and pattern of Hepatitis B among antenatal clinic attenders in Yaounde-Cameroon: is perinatal transmission of HBV neglected in Cameroon?
The prevalence of hepatitis B among pregnant women in Cameroon is high, and the pattern tends towards high infectivity and therefore increased risk of perinatal HBV transmission. Expand