Rates and patterns of great ape retrotransposition.

  title={Rates and patterns of great ape retrotransposition.},
  author={Fereydoun Hormozdiari and Miriam Konkel and Javier Prado-Martinez and Giorgia Chiatante and Irene Hernando Herraez and Jerilyn A. Walker and Benjamin Nelson and Can Alkan and Peter Sudmant and John Huddleston and Claudia Rita Catacchio and Arthur Ko and Maika Malig and C G J Baker and Tom{\`a}s Marqu{\`e}s-Bonet and Mario Ventura and Mark A. Batzer and Evan E. Eichler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 33},
We analyzed 83 fully sequenced great ape genomes for mobile element insertions, predicting a total of 49,452 fixed and polymorphic Alu and long interspersed element 1 (L1) insertions not present in the human reference assembly and assigning each retrotransposition event to a different time point during great ape evolution. We used these homoplasy-free markers to construct a mobile element insertions-based phylogeny of humans and great apes and demonstrate their differential power to discern ape… CONTINUE READING
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