Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.

@article{Brown1987RateOR,
  title={Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.},
  author={Edgar H. Brown and M. A. Iqbal and Simon Stuart and Kimi S. Hatton and J Valinsky and C. L. Schildkraut},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 1},
  pages={450-7}
}
We measured the temporal order of replication of EcoRI segments from the murine immunoglobulin heavy-chain constant region (IgCH) gene cluster, including the joining (J) and diversity (D) loci and encompassing approximately 300 kilobases. The relative concentrations of EcoRI segments in bromouracil-labeled DNA that replicated during selected intervals of… CONTINUE READING