Rate of protein folding near the point of thermodynamic equilibrium between the coil and the most stable chain fold.

@article{Finkelstein1997RateOP,
  title={Rate of protein folding near the point of thermodynamic equilibrium between the coil and the most stable chain fold.},
  author={Alexei V. Finkelstein and Badretdinov AYa},
  journal={Folding & design},
  year={1997},
  volume={2 2},
  pages={115-21}
}
BACKGROUND The problem of how a protein chain can find its most stable structure without exhaustive sorting of all its possible conformations is known as the 'Levinthal paradox'. The purpose of this paper is to elucidate this problem and to estimate the rate of folding to the most stable structure near the point of thermodynamic equilibrium between this structure and the coil. RESULTS Folding is rapid when it occurs in the vicinity of a thermodynamic 'all-or-none' transition from the coil to… CONTINUE READING

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