Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin


To determine the extent and time-course of hepatic and intestinal cytochrome P450 3A (CYP3A) inactivation due to the mechanism-based inhibitor clarithromycin. Intestinal and hepatic CYP3A inhibition was examined in 12 healthy volunteers following the administration of single and multiple doses of oral clarithromycin (500 mg). Intestinal biopsies were… (More)
DOI: 10.1007/s00228-012-1339-x


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