Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity

  title={Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity},
  author={Steve Dorus and Patrick Evans and Gerald J. Wyckoff and Sun Shim Choi and Bruce T. Lahn},
  journal={Nature Genetics},
Postcopulatory sperm competition is a key aspect of sexual selection and is believed to drive the rapid evolution of both reproductive physiology and reproduction-related genes. It is well-established that mating behavior determines the intensity of sperm competition, with polyandry (i.e., female promiscuity) leading to fiercer sperm competition than monandry. Studies in mammals, particularly primates, showed that, owing to greater sperm competition, polyandrous taxa generally have… 

Sexual selection on protamine and transition nuclear protein expression in mouse species

It is found that species with higher levels of sperm competition express less protamine 2 in relation to protamine 1 and transition nuclear proteins, and changes in gene regulatory sequences seem to be the basis of the evolutionary response to sexual selection in these proteins.

Rates of Evolution of Hominoid Seminal Proteins are Correlated with Function and Expression, Rather than Mating System

Estimated rates of evolution of a comprehensive set of proteins expressed in ejaculated semen show that these proteins in hominoids do not have elevated rates of nonsynonymous substitutions (Ka) compared with a control dataset of nonreproductive genes.

Sexual selection and the adaptive evolution of mammalian ejaculate proteins.

Evidence of a high rate of adaptive gene evolution linked to postcopulatory sexual selection in muroid rodents, a model vertebrate group displaying a broad range of mating systems, is sought and the action of sexual selection potentially responsible for elevated evolutionary rates may be difficult to detect on a gene-by-gene basis.

Comparative Sperm Proteomics in Mouse Species with Divergent Mating Systems

Comparisons revealed significant abundance differences amongst proteins involved in fertilization capacity, including those that govern sperm-zona pellucida interactions, axoneme components and metabolic proteins, and the identification of functionally coherent classes of proteins relating to sperm competition highlights the utility of evolutionary proteomic analyses.


It is speculated that the level of sperm competition is lower in more sexually dimorphic primates because males of these species monopolize access to fertile females more successfully, and variation in sperm competition may be driving the observed negative correlation of sequence evolution and sexual dimorphism in body weight.

Selection on sperm proteins depends on sperm competition in a pair of Lepidoptera

Investigation of the distribution of fitness effects of new non-synonymous mutations in monarch sperm confirms stronger selection on sperm proteins in monarchs, with very few neutral variants and weakly deleterious variants and a preponderance of strongly deleteriously variants.

Evolution of Protamine Genes and Changes in Sperm Head Phenotype in Rodents1

It is suggested that evolutionary changes in protamines could be related to complex developmental modifications in the sperm head, an important step toward understanding the role of changes in gene coding sequences in the divergence of germ cell phenotype.

Molecular evolution of seminal proteins in field crickets.

This paper characterizes these proteins in field crickets by combining an evolutionary expressed sequence tag screen of the male accessory gland in 2 focal species with a bioinformatics approach, and suggests that seminal protein genes evolve more rapidly than genes encoding proteins that are not involved with reproduction.

A proteomic study of sperm competition in mammals

Sperm competition, when sperm from more than one male compete to fertilise the same ova, has driven a diversity of adaptations. Increasingly, molecular techniques have been used to study the effect

Nonadaptive molecular evolution of seminal fluid proteins in Drosophila

A lack of sufficient evidence is highlighted to claim that most SFPs are driven to evolve rapidly by post-copulatory sexual selection while identifying genomic and functional attributes that influence different modes of S FPs evolution.



Evolution of the Hominoid Semenogelin Genes, the Major Proteins of Ejaculated Semen

It is suggested that structural changes in the semenogelin proteins that have arisen since the human–chimpanzee–gorilla split may be responsible for the physiological differences between these species ejaculated semen that correlate with their sociosexual behavior.

Sexual Selection, Seminal Coagulation and Copulatory Plug Formation in Primates

Results indicate that sexual selection has played an important role in the evolution of seminal coagulation, and copulatory plug function, in primates.

Sperm competition: Motility and the midpiece in primates

The results indicate that sexual selection by sperm competition has influenced the evolution of a specific component of male-gamete morphology, the volume of the sperm midpiece, in primate species with multiple-partner mating systems.

Reduced Polymorphism in the Chimpanzee Semen Coagulating Protein, Semenogelin I

The results suggest that there is a positive relationship between the intensity of sperm competition in a species and the strength of positive Darwinian selection on the seminal protein semenogelin I.

Sexual Selection and the Comparative Anatomy of Reproduction in Monkeys, Apes, and Human Beings

The effects of sexual selection upon the evolution of relative testes sizes, sperm morphology, seminal vesicular function, penile morphology, and copulatory behavior in the Order Primates is reviewed.

Testis weight, body weight and breeding system in primates

The hypothesis that selection will favour the male that can deposit the largest number of sperm means that the volume of spermatogenic tissue and hence testis size is far greater in the chimpanzee than in the gorilla or orangutan, and the results support the hypothesis.

A test of the role of copulatory plugs in sperm competition in deer mice (Peromyscus maniculatus)

A comparison of neotropical cricetine rodents (Muridae) with special reference to the phyllotine group and water economy and salt balance in a South American desert rodent Eligmodontia typus.

The rapid evolution of reproductive proteins

Sequence comparisons and functional studies are beginning to show the extent to which the rapid divergence of reproductive proteins is involved in the speciation process.

Sperm competition: Defining the rules of engagement

Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.

  • Z. Yang
  • Biology
    Molecular biology and evolution
  • 1998
The likelihood analysis confirmed most, but not all, conclusions Messier and Stewart reached using reconstructed ancestral sequences to estimate synonymous and nonsynonymous rates for different lineages.