Rate of glutamate synthesis from leucine in rat brain measured in vivo by 15N NMR.

@article{Kanamori1998RateOG,
  title={Rate of glutamate synthesis from leucine in rat brain measured in vivo by 15N NMR.},
  author={Keiko Kanamori and Brian D. Ross and Richard W Kondrat},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 3},
  pages={1304-15}
}
The rate of glutamate synthesis from leucine by the branched-chain aminotransferase was measured in rat brain in vivo at steady state. The rats were fed exclusively by intravenous infusion of a nutrient solution containing [15N]leucine. The rate of glutamate synthesis from leucine, determined from the rate of increase of brain [15N]glutamate measured by 15N NMR and the 15N enrichments of brain and blood leucine analyzed by gas chromatography-mass spectrometry, was 0.7-1.8 micromol/g/h at a… CONTINUE READING

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