Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans.

@article{Amiel1987RateOG,
  title={Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans.},
  author={Stephanie A. Amiel and Donald C Simonson and William V Tamborlane and Ralph A DeFronzo and Robert S. Sherwin},
  journal={Diabetes},
  year={1987},
  volume={36 4},
  pages={518-22}
}
To test the hypothesis that variations in rate of glucose fall influence counterregulatory hormone responses to hypoglycemia, we have modified the glucose-clamp technique to provide a reproducible hypoglycemic stimulus in normal and type I diabetic subjects that varied only in the rate of glucose fall. Responsive elevations in plasma epinephrine and norepinephrine and in growth hormone, glucagon, and cortisol were not significantly affected by a ninefold change in the rate at which plasma… CONTINUE READING

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