Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

@article{Byrne2010RateOF,
  title={Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis},
  author={Susan Byrne and Cathal Walsh and Catherine Lynch and Peter Bede and Marwa Elamin and Kevin P. Kenna and Russell Lewis McLaughlin and Orla Hardiman},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2010},
  volume={82},
  pages={623 - 627}
}
Background The population rate of familial amyotrophic lateral sclerosis (FALS) is frequently reported as 10%. However, a systematic review and meta-analysis of the true population based frequency of FALS has never been performed. Method A Medline literature review identified all original articles reporting a rate of FALS. Studies were grouped according to the type of data presented and examined for sources of case ascertainment. A systematic review and meta-analysis of reported rates of FALS… 
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  • S. Byrne, P. Bede, +4 authors O. Hardiman
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References

SHOWING 1-10 OF 88 REFERENCES
Amyotrophic lateral sclerosis a population study
TLDR
The present study lends further support to the impression that ALS has a remarkably uniform geographic distribution with Guam and the Kii peninsula of Japan being the only known areas with significantly high rates.
Incidence and Prevalence of Amyotrophic Lateral Sclerosis in Uruguay: A Population-Based Study
TLDR
ALS incidence is within a narrow range across countries despite the genetic, environmental and socioeconomic differences when similar prospective design, diagnosis criteria and data analyses are applied.
Incidence of amyotrophic lateral sclerosis in the Limousin region of France, 1997–2007
TLDR
Investigation of the incidence of ALS in Limousin between 1997 and 2007 found a high crude incidence, consistent with previous work published by European population-based registries, and showed a progressive increase up to 85 years, followed by a sharp decrease thereafter.
Prevalence of SOD1 mutations in the Italian ALS population
TLDR
The frequency of familial amyotrophic lateral sclerosis (FALS) was lower than that reported in series from ALS referral centers, and the frequency of SOD1 mutations in FALS was similar to the data reported in the literature.
Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study
TLDR
ALS incidence is within a narrow range across countries, with a peak between 65 and 75 years and a higher incidence in men, and a north to south latitude gradient of ALS incidence is not supported by the results of cohort studies.
A clinical epidemiological study of 251 cases of amyotrophic lateral sclerosis in the south of Brazil.
TLDR
Domestic work and heavy occupations appear to be related to precocious perception of the symptoms by interference with daily functions in patients with clinical forms of amyotrophic lateral sclerosis in Paraná, Brazil.
Large-scale SOD1 mutation screening provides evidence for genetic heterogeneity in amyotrophic lateral sclerosis
TLDR
It is demonstrated that SOD1 mutations are rare in The Netherlands in familial and SALS, which suggests that the genetic background of amyotrophic lateral sclerosis differs between different populations, countries and regions.
Prognosis in amyotrophic lateral sclerosis: A population-based study
TLDR
A recent article published in Neurology raises a concern for migraineurs who have concomitant restless legs syndrome (RLS), and suggests that droperidol or haloperidol could in fact be used as a diagnostic challenge, but the severity of some reactions would mitigate against this use.
Epidemiology of amyotrophic lateral sclerosis in Hordaland county, western Norway
TLDR
The incidence, prevalence and prognosis of amyotrophic lateral sclerosis in the county of Hordaland, western Norway were determined and the difference in survival between ALS with bulbar or spinal onset was not explained by age or sex differences in the two groups.
Descriptive Epidemiology of Amyotrophic Lateral Sclerosis in Japan, 1995-2001
TLDR
ALS mortality rates increased proportionally more for elderly population during the study period, with the peak in mortality in the 70- to 80-year old age group.
...
1
2
3
4
5
...