Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

  title={Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis},
  author={Susan Byrne and Cathal Walsh and Catherine Lynch and Peter Bede and Marwa Elamin and Kevin P. Kenna and Russell Lewis McLaughlin and Orla Hardiman},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  pages={623 - 627}
Background The population rate of familial amyotrophic lateral sclerosis (FALS) is frequently reported as 10%. However, a systematic review and meta-analysis of the true population based frequency of FALS has never been performed. Method A Medline literature review identified all original articles reporting a rate of FALS. Studies were grouped according to the type of data presented and examined for sources of case ascertainment. A systematic review and meta-analysis of reported rates of FALS… 

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  • S. ByrneP. Bede O. Hardiman
  • Psychology, Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2011
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