Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications.

@article{Veloso2014RateOE,
  title={Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications.},
  author={Artur Botelho Veloso and Killeen S. Kirkconnell and Brian Magnuson and Benjamin Biewen and Michelle T. Paulsen and Thomas E Wilson and Mats Ljungman},
  journal={Genome research},
  year={2014},
  volume={24 6},
  pages={896-905}
}
The rate of transcription elongation plays an important role in the timing of expression of full-length transcripts as well as in the regulation of alternative splicing. In this study, we coupled Bru-seq technology with 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) to estimate the elongation rates of over 2000 individual genes in human cells. This technique, BruDRB-seq, revealed gene-specific differences in elongation rates with a median rate of around 1.5 kb/min. We found that genes… CONTINUE READING
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References

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Coordinated regulation

B Tarrier, JG Washburn, R Lyons
2013

Ensembl 2013

AK Maunakea, L Huang, +4 authors MI Aladjem
Nucleic Acids Res • 2013

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