Rate of elimination of homologous globulins (including antibody) from the circulation.

@article{Humphrey1954RateOE,
  title={Rate of elimination of homologous globulins (including antibody) from the circulation.},
  author={J. Humphrey and A. Mcfarlane},
  journal={The Biochemical journal},
  year={1954},
  volume={57 2},
  pages={
          186-91
        }
}
Schoenheimer, Ratner, Rittenberg & Heidelberger (1942) and Heidelberger, Treffers, Schoenheimer, Ratner & Rittenberg (1942) showed that pneumococcus antibodies are synthesized and eliminated from the circulation in actively immunized rabbits in much the same way as other 15N-labelled plasma proteins, and also that antibodies passively transfused to a non-immune animal do not incorporate 15N administered as glycine in the diet. They arrived at a half-life for antibody and normal plasma proteins… Expand
HYPOTHYROIDISM ON ANTIBODY PRODUCTION AND DECAY RATES
TLDR
The effect of experimentally induced hypothyroidism on the rate of antibody synthesis,hesis and catabolism was studied in albino rabbits. Expand
GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE
TLDR
Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I131 24 times in 13 control rabbits before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine and no differences were noted in the metabolism of homologous or autologous Gamma globulin regardless of the allotypic specificities. Expand
A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates.
The effect of hypothyroidism induced by intravenous injections of I/sup 131/ on antibody production, the anamnestic response, and on antibody decay rate, compared to normal animals, was studied in 63Expand
Catabolism of plasma enzymes, as studied with 125I-labeled lactate dehydrogenase-1 in the rabbit.
TLDR
It is concluded that removal of the enzyme protein or its breakdown products is a passive process, andreciable radioactivity was detected in the intestinal contents, a finding which suggests that removal via the small intestine is an important route for the removal of inactivated enzyme products from the circulation. Expand
BIOSYNTHETIC DETERMINATIONWITH RADIOACTIVE SULFUR OF TURN-OVER RATES OF VARIOUS PLASMAPROTEINS IN NORMALAND CIRRHOTIC MAN
Data concerning the life-span of various human plasma proteins are yet meager. Methods have been difficult and data often uncertain of interpretation. Approximations have depended chiefly uponExpand
Protein synthesis in mammalian cells with particular reference to antibody formation
Recent work concerned with protein biosynthesis in mammalian systems is reviewed. Antibody protein was chosen as an example of a specific protein and its formation and secretion was studied in slicesExpand
The fate of circulating lactate dehydrogenase-5 in the rabbit.
TLDR
Results suggest that further breakdown in the intestine is followed by absorption of the products, which are excreted in the urine, and suggests that discharge via the small intestine is a major route whereby inactivated enzyme fragments are removed from the circulation. Expand
EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM γ-GLOBULIN CONCENTRATION ON γ-GLOBULIN CATABOLISM
  • S. Sell
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1964
TLDR
A feedback mechanism for the control of the serum γ-globulin concentration appears to be operative in the mouse, but not in the guinea pig, while Guinea pigs immunized with antigens in complete Freund's adjuvant or a saline suspension of killed E. coli had an increase in the catabolic rates of all labeled proteins tested including human serum albumin. Expand
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY
Rapid formation of poliovirus-neutralizing antibody was observed in the rabbit. 19S type antibody was detectable 8 to 12 hours following a single intravenous virus injection and the induction periodExpand
On the kinetics of turnover of serum albumin.
TLDR
It was found that partition of albumin between the intra- and extra-vascular fluids and re-utilization of labeled amino acids arising through the breakdown of body proteins can account for the particular kinetics observed under different conditions. Expand
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