Rate of decline of percentage CD4+ cells is faster in HIV-1 than in HIV-2 infection.

  title={Rate of decline of percentage CD4+ cells is faster in HIV-1 than in HIV-2 infection.},
  author={Shabbar Jaffar and Andrew N J Wilkins and Pa Tamba Ngom and Saihou Sabally and Tumani Corrah and J E Bangali and Matthew Rolfe and Hilton C. Whittle},
  journal={Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association},
  volume={16 5},
Increasing evidence suggests that the pathogenesis of HIV-1 is different from that of HIV-2. Thus, we have measured, longitudinally at various times over a median follow-up of 2.1 years, the percentage CD4+ cells of 94 patients infected with HIV-1 and 164 patients infected with HIV-2. The pattern of decline of CD4% over time was linear for patients with either infection. Multilevel statistical modeling techniques showed that after stratifying for HIV status, the rate of decline of CD4% was… CONTINUE READING

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