Rate of clearance of interleukin-1 from the blood of normal and nephrectomized rats.


Interleukin-1 (IL-1), a macrophage product, appears to be responsible for a wide variety of changes in animals during the early stages of infection and inflammation. However, the fate of injected IL-1 has not been established. The major pathway of removal from the circulation may be through the kidney, since IL-1 can be found in urine. The IL-1 for these… (More)