Rate of binding of various inhibitors at the dopamine transporter in vivo

  title={Rate of binding of various inhibitors at the dopamine transporter in vivo},
  author={Marigo J Stathis and Ursula A Scheffel and Susan Zemyan Lever and John W. Boja and Michael Kuhar and F Ivy Carroll},
The rate of entry of drugs into brain is thought to be a factor in their abuse liability. In this investigation, we have examined the rate of entry and binding at dopamine transporters in mouse striatum for a variety of dopamine transporter inhibitors. The method utilized was based on measuring the displacement of3H-WIN 35,428 from striatal dopamine transporter sites in vivo at different times. Eleven cocaine analogs (RTI-31, RTI-32, RTI-51, RTI-55, RTI-113, RTI-114, RTI-117, RTI-120, RTI-121… CONTINUE READING


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