Rate of Recombinational Deletion among Human Endogenous Retroviruses

@article{Belshaw2007RateOR,
  title={Rate of Recombinational Deletion among Human Endogenous Retroviruses},
  author={R. Belshaw and J. Watson and A. Katzourakis and A. Howe and John Woolven-Allen and A. Burt and M. Tristem},
  journal={Journal of Virology},
  year={2007},
  volume={81},
  pages={9437 - 9442}
}
ABSTRACT The fate of most human endogenous retroviruses (HERVs) has been to undergo recombinational deletion. This process involves homologous recombination between the flanking long terminal repeats (LTRs) of a full-length element, leaving a relic structure in the genome termed a solo LTR. We examined loci in one family, HERV-K(HML2), and found that the deletion rate decreased markedly with age: the rate among recently integrated loci was almost 200-fold higher than that among loci whose… Expand
99 Citations
Effects of Recombination Rate on Human Endogenous Retrovirus Fixation and Persistence
  • 44
  • PDF
Variation in proviral content among human genomes mediated by LTR recombination
  • 29
  • PDF
The evolutionary dynamics of endogenous retroviruses
  • Highly Influenced
Mammalian Endogenous Retroviruses.
  • 97
Recombination marks the evolutionary dynamics of a recently endogenized retrovirus
  • PDF
Sex-specific aspects of endogenous retroviral insertion and deletion
  • 2
  • PDF
The decline of human endogenous retroviruses: extinction and survival
  • 40
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution.
  • J. Hughes, J. Coffin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
  • 183
  • Highly Influential
  • PDF
Long-term reinfection of the human genome by endogenous retroviruses.
  • 334
  • PDF
Insertional polymorphisms of full-length endogenous retroviruses in humans
  • 330
  • PDF
Suppression of intrachromosomal gene conversion in mammalian cells by small degrees of sequence divergence.
  • 62
  • PDF
Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.
  • 225
  • PDF
High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection.
  • 115
  • PDF
Somatic and germ-line reverse mutation rates of the retrovirus-induced dilute coat-color mutation of DBA mice.
  • 58
  • Highly Influential
  • PDF
Role of endogenous retroviruses as mutagens: The hairless mutation of mice
  • 197
...
1
2
3
4
5
...