Rate-limiting steps in the interconversion of purine ribonucleotides in Ehrlich ascites tumor cells in vitro.

The conversion of inosinate to guanylate in Ehrlich ascites tumor cells incubated in vitro in Krebs-Ringer phosphate medium is limited first by the concentration of glutamine and then by the concentration of inosinate. The conversion of inosinate to adenylate is limited by the concentration of aspartate. Adenylate conversion to guanylate is limited first by… (More)

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