Rate-limiting steps in RNA chain initiation.

  title={Rate-limiting steps in RNA chain initiation.},
  author={William R. McClure},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 10},
Promoter-specific lags in the approach to the steady-state rate of abortive initiation were observed when Escherichia coli RNA polymerase was added to initiate the reaction. The lag times were related to the time required for free enzyme and free promoter to combine and isomerize into a functionally active complex. The lag times measured for several bacteriophage and bacterial promoters differed widely (10 sec to several minutes) and in most cases corresponded to the rate-limiting step in the… CONTINUE READING
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